Zhang et al. Acetylation Enhances TET2 Function in Protecting against Abnormal DNA Methylation during Oxidative Stress Molecular Cell. 2017; 65;2 -323
Previous studies have revealed the function of the ten-eleven translocation (TET) family of proteins in DNA demethylation, now researchers from the Johns Hopkins University School of Medicine have further elucidated the mechanism by which the TET2 protein protects against abnormal DNA methylation in cancer cells. The researchers demonstrated that acetylation of TET2 increases enzymatic activity of the protein and enhances its interaction with DNA (cytosine-5)-methyltransferase 1 (DNMT1). The binding with DNMT1 further increases the stability of the TET2 protein and localises the protein to chromatin where it can prevent accumulation of DNA methylation by converting 5mC to 5hmC.